Clinical Features Of Hyperlipidaemia Hyperlipidaemia may present to the clinician in several ways. Unfortunately, however, the first manifestation is often a cardiovascular event. There are three main clinical manifestations of hyperlipidaemia: increased clinical consequences of atherosclerosis; cutaneous manifestations of hyperlipidaemia; and the chylomicronaemia syndrome that can occur when chylomicrons accumulate chronically. As screening for hyperlipidaemia becomes more commonplace, asymptomatic cases are being detected more frequently. See later: • Increased Atherosclerosis Risk • Xanthomata • Xanthelasma • Corneal Arcus • Chylomicronaemia Syndrome